Yes. They don't cancel each other out, but both can be drying, so it's best not to layer them in the same step.
Why
Salicylic acid isn't known to deactivate retinoids, and a small study found a routine combining salicylic acid, azelaic acid and retinol well tolerated. Layering both at once raises the chance of dryness and peeling. Unlike glycolic acid, 2% salicylic acid didn't increase the skin's sensitivity to UV light in an FDA study, so it can go in the morning under sunscreen. In the US, salicylic acid is also an OTC drug ingredient in some products; if yours has a Drug Facts label, follow its directions first.
How to use them
Use salicylic acid in the morning and retinol at night, or keep both in the evening on alternate nights. If your skin feels dry or tight, use the salicylic acid less often.
BHA is regulated as an OTC drug active in some products in the US. The directions on the product's label come first, and Dermo doesn't recommend specific drug products.
Sources
- 1The effects of topically applied glycolic acid and salicylic acid on ultraviolet radiation-induced erythema, DNA damage and sunburn cell formation in human skin · Journal of Dermatological Science, 2009
- 2A randomized controlled double-blinded split-face prospective clinical trial to assess the efficacy, safety, and tolerability of a novel 3-step routine compared to benzoyl peroxide for the treatment of mild to moderate acne vulgaris · Archives of Dermatological Research, 2024
- 3Beta Hydroxy Acids · U.S. Food and Drug Administration, 2022
General cosmetic information, not medical advice. Written with AI assistance from the sources above; updated October 2026.