Generally, yes. PHAs such as gluconolactone and lactobionic acid are among the gentlest exfoliating acids and have been used alongside retinoids with good tolerance.
Why
PHAs exfoliate like AHAs but with less stinging, and they also draw water into the skin, which can help with retinoid dryness. Research describes PHA products being well tolerated with a retinoid, and a cream combining PHAs with a retinyl ester giving smoothing benefits. The evidence comes from a small number of studies, so it's promising rather than proven, and any exfoliant can still add to irritation on sensitive skin.
How to use them
You can use a PHA before your retinol at night, or move the PHA to the morning if your skin feels sensitive. Introduce one new product at a time.
Sources
- 1The use of polyhydroxy acids (PHAs) in photoaged skin · Cutis, 2004
- 2Applications of hydroxy acids: classification, mechanisms, and photoactivity · Clinical, Cosmetic and Investigational Dermatology, 2010
General cosmetic information, not medical advice. Written with AI assistance from the sources above; updated October 2026.