Can you use benzoyl peroxide with glycolic acid?
Yes, but not in the same step. Both can dry and irritate the skin, so use benzoyl peroxide in the morning and the AHA at night.
Why
There's no known chemical reaction between them; the concern is added dryness, redness and peeling. Benzoyl peroxide's label warns about irritation and advises sunscreen, and AHAs also increase sensitivity to UV light, which makes evening the better time for the acid. Benzoyl peroxide is an OTC drug ingredient in the US, so its label directions come first.
How to use them
Apply benzoyl peroxide in the morning, followed by sunscreen, and the AHA at night. If dryness builds up, use the AHA only a few nights a week.
Benzoyl peroxide is regulated as an OTC drug in the US. The directions on the product's label come first, and Dermo doesn't recommend specific drug products.
Sources
- 121 CFR 333.350 - Labeling of acne drug products · Electronic Code of Federal Regulations (eCFR), 2016
- 2Alpha Hydroxy Acids · U.S. Food and Drug Administration, 2022
General cosmetic information, not medical advice. Written with AI assistance from the sources above; updated October 2026.